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The molecular mechanism is not completely knownbut may be triggered by high transmethylation rates and hyper production of Hcy [53]. Prevalence of MR evidence of diffuse axonal injury in patients with mild head injuryand normal head CT findings. procumbens standardized to 100mg harpagoside per day, versus a lower dose of 50 mg harpagoside, or aplacebo

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A high coherence of slow wave fluctuations of TCD-FV and NIRS-TOI signals inthe slow wave spectrum was found in a clinical study of sepsis patients (71) and this led tothe definition of TOx (other authors also call it COx), which is the moving correlation coef-ficient between slow waves in TOI and CPP. Typical visual auraconsisting of scintillating scotomas are highly characteris-tic of migraine, especially when they are gradual in onsetand progressive (Aring, 1972).

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