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Metabolomics was initially referred to as metabolicchanges within a cell, while metabonomics was the meta-bolic changes within a biological system. Death row women, for example, spend an aver-age of twenty-two hours alone in their cells. Despite this finding associated with the inability ofTregs to home to the vitiligo lesions, another more substantial study revealed that there wasindeed a functional defect in Tregs among generalized vitiligo patients

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As a consequence of the body having only alimited number of P450s with which to oxidatively metabo-lize hundreds of drugs and xenobiotics, when inhibitoryinteractions do occur, the mechanism is often simple compe-tition for limited amounts of enzyme (Figure 2.9a). Pre- and postbroncho-dilation PFTs are an appropriate assessment if the patient is currently short of breath tosee if there is improvement, but they are of no value in an asymptomatic patient. Selective blockade of AT1 receptorswith ARBs leaves the AT2 receptors open for stimulation byangiotensin II. A cell that hasdouble-strand breaks can be repaired by joining the freeDNA ends.
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